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KMID : 0895820190290040029
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Journal of Oriental Rehabilitation Medicine
2019 Volume.29 No. 4 p.29 ~ p.45
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Anti-obesity Effects of Banggihwnggi-tang-hap-yeonggyechulgam-tang in High Fat Diet Induced Obese Mice Model
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Kim Tae-Ryeong
Kim Young-Jun
Woo Chang-Hoon
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Abstract
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Objectives: This study is to investigate anti-obesity effects of Banggihwanggitang-hap-yeonggyechulgam-tang (BY), an herbal formula, in high fat diet induced obese mice model.
Methods: Fourty five male C57Bl/6J mice were randomly assigned to normal group fed with normal research diet (Nor, n=9), high fat diet control group treated with water (Veh, n=9), high fat diet group treated with orlistat (Oris; n=9, Orlistat 40 mg/kg), high fat diet group treated with low concentraion BY (BYL; n=6, BY 0.87 g/kg) and high fat diet group treated with high concentration BY (BYH; n=6, BY 1.74 g/kg).
Results: Seven weeks later, antioxidative capacity, body weight, epididymal fat pad and liver weight, reactive oxygen species (ROS), peroxynitrite (ONOO-), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), superoxide dismutase (SOD), catalase, glutathione peroxidase (Gpx), heme oxygenase (HO)-1 and histology of liver were evaluated. In the BYH group, 1,1-diphenyl-2-picrylhydrazyl and 2,2’-azinobis (3 ethybenzothiazoline-6-sulfonic acid) radical scavenging activity were more than L-ascorbic acid. Body weight gain were significantly less than Veh group. Epididymal fat pad and liver weight gain were significantly less than Veh group. ROS and ONOO- were significantly less than with Veh group. ALT and AST were significantly less than with Veh group. Total cholesterol, triglyceride and LDL were significantly less, HDL were significantly more than Veh group. SOD, catalase, Gpx, HO-1 significantly increased compared with Veh group. Injury on liver was lesser than Veh group.
Conclusions: It can be suggested that BY has anti-obesity effects in high fat diet induced obese mice model.
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KEYWORD
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Banggihwanggi-tang-hap-yeonggyechulgam-tang, Obesity, High-fat diet, Antioxidants, Dyslipidemia
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